Genetic polymorphism of the growth arrest-specific 6 gene is associated with cutaneous vasculitis in Taiwanese patients with systemic lupus erythematosus

• Published in: Clinical rheumatology Vol. 31; no. 10; pp. 1443 - 1448
• Main Authors: Wu, Chien-Sheng, Hu, Chung-Yi, Chan, Cheng-Ju, Chang, Sheng-Kai, Hsu, Ping-Ning
• Format: Journal Article
• Language: English
• Published: London Springer-Verlag 01.10.2012; Springer Nature B.V
• Subjects: Adult; Asian Continental Ancestry Group - ethnology; Asian Continental Ancestry Group - genetics; Case-Control Studies; Comorbidity; Female; Gene Frequency; Genetic Predisposition to Disease - ethnology; Genetic Predisposition to Disease - genetics; Genotype; Humans; Intercellular Signaling Peptides and Proteins - genetics; Lupus Erythematosus, Systemic - epidemiology; Lupus Erythematosus, Systemic - ethnology; Lupus Erythematosus, Systemic - genetics; Male; Medicine; Medicine & Public Health; Middle Aged; Original Article; Polymorphism, Single Nucleotide - genetics; Rheumatology; Taiwan; Vasculitis, Leukocytoclastic, Cutaneous - epidemiology; Vasculitis, Leukocytoclastic, Cutaneous - ethnology; Vasculitis, Leukocytoclastic, Cutaneous - genetics; Taiwan; (; Systemic lupus erythematosus (SLE); gene; Single-nucleotide polymorphism (SNP)
• ISSN: 0770-3198; 1434-9949; 1434-9949
• DOI: 10.1007/s10067-012-2027-z

The growth arrest-specific 6 ( GAS6 ) gene product participates in platelet activation and granulocyte interaction with the endothelium. Our case–control study aimed to determine whether polymorphism of GAS6 was associated with predisposing risk or specific clinical manifestations of systemic lupus erythematosus (SLE). Two of the single-nucleotide polymorphisms (SNPs) of the GAS6 gene, GAS6 834 + 7G/A (rs8191974) and GAS6 +1332C/T (rs1803628), were investigated in 83 SLE patients and 89 non-lupus control subjects. We demonstrated that among lupus patients, the GAS6 +1332 T allele was more prevalent in patients with cutaneous vasculitis (allele T 41.7 % in patients with cutaneous vasculitis compared with 18.3 % in patients without vasculitis, odds ratio (OR) 3.2, 95 % confidence interval 1.3–8.0, p  = 0.016). In conclusion, GAS6 polymorphism is positively associated with cutaneous vasculitis in SLE patients, which suggests that GAS6 polymorphism could be a genetic marker for SLE with cutaneous vasculitis.