Detection of Autoantibodies and Increased Concentrations of Interleukins in Plasma from Patients with Tourette's Syndrome
The aim of this study was to assess levels of autoantibodies and cytokines in patients with Tourette's syndrome (TS, n = 40) and healthy control individuals ( n = 40). Plasma interleukin (IL)-1β, IL-6, IL-17, and soluble gp130 concentrations were significantly higher in the TS group compared...
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Published in | Journal of molecular neuroscience Vol. 48; no. 1; pp. 219 - 224 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
New York
Humana Press Inc
01.09.2012
Springer Nature B.V |
Subjects | |
Online Access | Get full text |
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Summary: | The aim of this study was to assess levels of autoantibodies and cytokines in patients with Tourette's syndrome (TS,
n
= 40) and healthy control individuals (
n
= 40). Plasma interleukin (IL)-1β, IL-6, IL-17, and soluble gp130 concentrations were significantly higher in the TS group compared with the control group (
P
< 0.001); whereas the soluble IL-6 receptor concentration was significantly decreased in the TS group compared with the control group (
P
< 0.001). Significantly more patients in the TS group were positive for antibrain and antinuclear antibodies, and antistreptolysin compared with the control group (
P
< 0.05). These findings suggest that immune activity is altered in patients with TS. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-1 |
ISSN: | 0895-8696 1559-1166 |
DOI: | 10.1007/s12031-012-9811-8 |