Detection of Autoantibodies and Increased Concentrations of Interleukins in Plasma from Patients with Tourette's Syndrome

• Published in: Journal of molecular neuroscience Vol. 48; no. 1; pp. 219 - 224
• Main Authors: Cheng, Yu-hang, Zheng, Yi, He, Fan, Yang, Jian-hong, Li, Wen-biao, Wang, Min-ling, Cui, De-yan, Chen, Ying
• Format: Journal Article
• Language: English
• Published: New York Humana Press Inc 01.09.2012; Springer Nature B.V
• Subjects: Adolescent; Antibodies; Antigens; Antinuclear antibodies; Autoantibodies; Autoantibodies - blood; Biomarkers - blood; Biomedical and Life Sciences; Biomedicine; Cell Biology; Child; Cytokine Receptor gp130 - blood; Cytokines; Diabetes; Female; Gilles de la Tourette syndrome; Glycoprotein gp130; Hospitals; Humans; Infections; Interleukin 17; Interleukin 6; Interleukin 6 receptors; Interleukin-17 - blood; Interleukin-1beta - blood; Interleukin-6 - blood; Interleukins - blood; Lupus; Lymphocytes - immunology; Lymphocytes - metabolism; Male; Nervous system; Neurochemistry; Neurology; Neurosciences; Pathogenesis; Plasma; Proteomics; Receptors, Interleukin-6 - blood; Rheumatoid arthritis; Seroepidemiologic Studies; Tourette syndrome; Tourette Syndrome - blood; Tourette Syndrome - epidemiology; Tourette Syndrome - immunology; Young Adult; Beijing China; China; Tourette's syndrome; Autoantibodies; Interleukins; sIL-6R; sgp130
• ISSN: 0895-8696; 1559-1166
• DOI: 10.1007/s12031-012-9811-8

The aim of this study was to assess levels of autoantibodies and cytokines in patients with Tourette's syndrome (TS, n  = 40) and healthy control individuals ( n  = 40). Plasma interleukin (IL)-1β, IL-6, IL-17, and soluble gp130 concentrations were significantly higher in the TS group compared with the control group ( P  < 0.001); whereas the soluble IL-6 receptor concentration was significantly decreased in the TS group compared with the control group ( P  < 0.001). Significantly more patients in the TS group were positive for antibrain and antinuclear antibodies, and antistreptolysin compared with the control group ( P  < 0.05). These findings suggest that immune activity is altered in patients with TS.