Linking morphological and functional variability in hand movement and silent reading

• Published in: Brain Structure and Function Vol. 221; no. 7; pp. 3361 - 3371
• Main Authors: Sun, Z. Y., Pinel, P., Rivière, D., Moreno, A., Dehaene, S., Mangin, J.-F.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.09.2016; Springer Nature B.V
• Subjects: Biomedical and Life Sciences; Biomedicine; Brain Mapping; Cell Biology; Hand - physiology; Hands; Humans; Magnetic Resonance Imaging; Morphology; Motor Activity; Motor Cortex - anatomy & histology; Motor Cortex - physiology; Neurology; Neurosciences; Original Article; Reading; Studies; Temporal Lobe - anatomy & histology; Temporal Lobe - physiology; STS; Cortical folding; Functional activation; Variability; Central sulcus; Hand knob
• ISSN: 1863-2653; 1863-2661; 0340-2061
• DOI: 10.1007/s00429-015-1106-8

It is generally accepted in neuroscience that anatomy and function go hand in hand. Accordingly, a local morphological variability could lead to a corresponding functional variability. In this study, we tested this hypothesis by linking the variability of the cortical folding pattern of 252 right-handed subjects to the localization or the pattern of functional activations induced by hand motion or silent reading. Three regions are selected: the central sulcus, the precentral sulcus and the superior temporal sulcus (STS). “Essential morphological variability traits” are identified using a method building upon multidimensional scaling. The link between variability in anatomy and function is confirmed by the perfect match between the central sulcus morphological “hand knob” and the corresponding motor activation: as the location of the hand knob moves more or less dorsally along the central sulcus, the motor hand activation moves accordingly. Furthermore, the size of the left hand activation in the right hemisphere is correlated with the knob location in the central sulcus. A new link between functional and morphological variability is discovered relative to the location of a premotor activation induced by silent reading. While this reading activation is located next to the wall of the central sulcus when the hand knob has a ventral positioning, it is pushed into a deep gyrus interrupting the precentral sulcus when the knob is more dorsal. Finally, it is shown that the size of the reading activation along the STS is larger when the posterior branches are less developed.