Signal Transduction in Cancer

Cancer is driven by genetic and epigenetic alterations that allow cells to overproliferate and escape mechanisms that normally control their survival and migration. Many of these alterations map to signaling pathways that control cell growth and division, cell death, cell fate, and cell motility, an...

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Bibliographic Details
Published inCold Spring Harbor perspectives in medicine Vol. 5; no. 4; p. a006098
Main Authors Sever, R., Brugge, J. S.
Format Journal Article
LanguageEnglish
Published United States Cold Spring Harbor Laboratory Press 01.04.2015
Subjects
Cell Movement
Cell Polarity
Cell Proliferation
Concepts
Genomic Instability
Humans
MAP Kinase Signaling System
Mutation
Neoplasms - genetics
Oncogenes
Phosphatidylinositol 3-Kinases - genetics
Proto-Oncogene Proteins c-akt - genetics
Tumor Microenvironment
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Summary:Cancer is driven by genetic and epigenetic alterations that allow cells to overproliferate and escape mechanisms that normally control their survival and migration. Many of these alterations map to signaling pathways that control cell growth and division, cell death, cell fate, and cell motility, and can be placed in the context of distortions of wider signaling networks that fuel cancer progression, such as changes in the tumor microenvironment, angiogenesis, and inflammation. Mutations that convert cellular proto-oncogenes to oncogenes can cause hyperactivation of these signaling pathways, whereas inactivation of tumor suppressors eliminates critical negative regulators of signaling. An examination of the PI3K-Akt and Ras-ERK pathways illustrates how such alterations dysregulate signaling in cancer and produce many of the characteristic features of tumor cells.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ISSN:2157-1422
2472-5412
DOI:10.1101/cshperspect.a006098