Parvovirus Diversity and DNA Damage Responses

• Published in: Cold Spring Harbor perspectives in biology Vol. 5; no. 2; p. a012989
• Main Authors: Cotmore, S. F., Tattersall, P.
• Format: Journal Article
• Language: English
• Published: United States Cold Spring Harbor Laboratory Press 01.02.2013
• Subjects: DNA Damage; DNA Replication; DNA, Viral - chemistry; Genetic Variation; Genome, Viral; Parvovirus - genetics; Parvovirus - pathogenicity; Parvovirus - physiology; Virus Replication - genetics; Virus Replication - physiology

Parvoviruses have a linear single-stranded DNA genome, around 5 kb in length, with short imperfect terminal palindromes that fold back on themselves to form duplex hairpin telomeres. These contain most of the cis-acting information required for viral "rolling hairpin" DNA replication, an e...