Parvovirus Diversity and DNA Damage Responses

Parvoviruses have a linear single-stranded DNA genome, around 5 kb in length, with short imperfect terminal palindromes that fold back on themselves to form duplex hairpin telomeres. These contain most of the cis-acting information required for viral "rolling hairpin" DNA replication, an e...

Full description

Saved in:
Bibliographic Details
Published inCold Spring Harbor perspectives in biology Vol. 5; no. 2; p. a012989
Main Authors Cotmore, S. F., Tattersall, P.
Format Journal Article
LanguageEnglish
Published United States Cold Spring Harbor Laboratory Press 01.02.2013
Subjects
DNA Damage
DNA Replication
DNA, Viral - chemistry
Genetic Variation
Genome, Viral
Parvovirus - genetics
Parvovirus - pathogenicity
Parvovirus - physiology
Virus Replication - genetics
Virus Replication - physiology
Online AccessGet full text

Cover

More Information
Summary:Parvoviruses have a linear single-stranded DNA genome, around 5 kb in length, with short imperfect terminal palindromes that fold back on themselves to form duplex hairpin telomeres. These contain most of the cis-acting information required for viral "rolling hairpin" DNA replication, an evolutionary adaptation of rolling-circle synthesis in which the hairpins create duplex replication origins, prime complementary strand synthesis, and act as hinges to reverse the direction of the unidirectional cellular fork. Genomes are packaged vectorially into small, rugged protein capsids ~260 Å in diameter, which mediate their delivery directly into the cell nucleus, where they await their host cell's entry into S phase under its own cell cycle control. Here we focus on genus-specific variations in genome structure and replication, and review host cell responses that modulate the nuclear environment.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ISSN:1943-0264
1943-0264
DOI:10.1101/cshperspect.a012989