AgNPs-decorated 3D printed PEEK implant for infection control and bone repair
[Display omitted] •Additive manufacturing was used to fabricate 3D PEEK scaffold.•Sliver nanoparticles were evenly anchored on the surface of 3D PEEK scaffold.•The 3D PEEK/Ag have dual functions, i.e. osteogenesis and antibacterial property. Polyetheretherketone (PEEK) is an ideal substitute materia...
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Published in | Colloids and surfaces, B, Biointerfaces Vol. 160; pp. 483 - 492 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Netherlands
Elsevier B.V
01.12.2017
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Subjects | |
Online Access | Get full text |
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Summary: | [Display omitted]
•Additive manufacturing was used to fabricate 3D PEEK scaffold.•Sliver nanoparticles were evenly anchored on the surface of 3D PEEK scaffold.•The 3D PEEK/Ag have dual functions, i.e. osteogenesis and antibacterial property.
Polyetheretherketone (PEEK) is an ideal substitute material for bone tissue engineering, which can avoid the stress shielding phenomenon due to its similar mechanical properties to natural human bone. Complex bone defect and postoperative infection are still two enormous challenges in orthopedic clinics. It’s well-known that additive manufacturing possesses the merits of high-precision and rapid prototyping, thus it easily meets the needs of mold processing. In the present study, we developed a novel Ag-decorated 3D printed PEEK via catecholamine chemistry. SEM image showed that silver nanoparticles (AgNPs) were evenly anchored on the surface. The following antibacterial tests, including bacterial inhibition ring, bacterial dynamics curves and antibiofilm test, indicated that the Ag-decorated 3D PEEK scaffolds displayed significant antibacterial effect towards Gram-negative and Gram-positive bacteria. Then MG-63 cells were seeded on samples for cell proliferation and ALP activity tests. The results demonstrated the scaffold modified with AgNPs could support cell proliferation, and enhanced higher alkaline phosphatase activity compared with pure PEEK scaffold. Expectedly, this dual functional 3D material holds great potential application in clinical bone tissue repair. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0927-7765 1873-4367 |
DOI: | 10.1016/j.colsurfb.2017.09.061 |