Milkers' Nodules Complicated by Erythema Multiforme and Graft-versus-Host Disease after Allogeneic Hematopoietic Stem Cell Transplantation for Multiple Myeloma

We describe a case of cow-transmitted parapoxvirus infection—also known as milkers' nodules—after a hematopoietic stem cell transplantation for multiple myeloma. The infection was complicated by erythema multiforme and acute exacerbation of graft-versus-host disease. Parapoxvirus was confirmed...

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Bibliographic Details
Published inClinical infectious diseases Vol. 40; no. 7; pp. e63 - e66
Main Authors Slattery, Wendolyn R., Juckett, Mark, Agger, William A., Radi, Craig A., Mitchell, Teri, Striker, Rob
Format Journal Article
LanguageEnglish
Published United States The University of Chicago Press 01.04.2005
Oxford University Press
Subjects
Adult
Erythema Multiforme - complications
Graft vs Host Disease - complications
Graft vs Host Disease - drug therapy
Hematopoietic Stem Cell Transplantation - adverse effects
Humans
Immunosuppressive Agents - therapeutic use
Male
Multiple Myeloma - therapy
Parapoxvirus
Poxviridae Infections - complications
Poxviridae Infections - pathology
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Summary:We describe a case of cow-transmitted parapoxvirus infection—also known as milkers' nodules—after a hematopoietic stem cell transplantation for multiple myeloma. The infection was complicated by erythema multiforme and acute exacerbation of graft-versus-host disease. Parapoxvirus was confirmed by electron microscopy. The natural history of milker's nodules in immunocompetent hosts is described and compared to that in our immunocompromised patient.
Bibliography:istex:11501075D4F7B44C9C3609B5FFC40234A071BC67
ark:/67375/HXZ-7CHMDGPM-7
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ISSN:1058-4838
1537-6591
DOI:10.1086/428619