Selective Expression of Progesterone Receptor in Malignant Melanoma Was Inversely Correlated with PCNA

• Published in: Journal of Huazhong University of Science and Technology. Medical sciences Vol. 28; no. 2; pp. 216 - 218
• Main Author: 李家文 方险峰 陈旭娥 陈静
• Format: Journal Article
• Language: English
• Published: Heidelberg Huazhong University of Science and Technology 01.04.2008; Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
• Subjects: Animals; Female; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Male; Medicine; Medicine & Public Health; Melanoma - metabolism; Mice; Middle Aged; Models, Biological; Prognosis; Proliferating Cell Nuclear Antigen - metabolism; Receptors, Progesterone - biosynthesis; Receptors, Progesterone - genetics; Skin - metabolism; Skin Neoplasms - metabolism; 恶性黑素瘤; 治疗方法; 皮肤病; progesterone receptor; malignant melanoma
• ISSN: 1672-0733; 1993-1352
• DOI: 10.1007/s11596-008-0226-2

To investigate the role of progesterone receptor （PR） expression in malignant melanoma （MM）, PR and proliferative cell nuclear antigen （PCNA） expression were immunohistochemistrically evaluated in a series of 35 specimens of MM, and the correlation between the immunohistochemistrical findings and clinicopathological data was also analyzed. PR expression was detected in 25.7% （9/35） of the patients with MM. No PR expression was observed in nevi. PR expression was inversely correlated with PCNA expression （r=-0.353, P=-0.026）. PR expression was slightly increased in females, subjects aged under 55 y, those with ulceration, non-acral subtype and diagnosis delay longer than 1 y, but the difference was not statistically significant. Selective expression of progesterone receptor in malignant melanoma might be correlated with inhibited tumor growth.