Association between TGF-β gene polymorphism and myopia: A systematic review and meta-analysis

• Published in: Medicine (Baltimore) Vol. 101; no. 30; p. e29961
• Main Authors: Zhu, Xiaoyu, Xu, Bowei, Dai, Lingxue, Wang, Zuoyuan, Feng, Li, Zhao, Jiangyue
• Format: Journal Article
• Language: English
• Published: United States Lippincott Williams & Wilkins 29.07.2022
• Subjects: Alleles; Genetic Predisposition to Disease; Humans; Myopia - genetics; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Systematic Review and Meta-Analysis; Transforming Growth Factor beta1 - genetics; Transforming Growth Factor beta1 - therapeutic use
• ISSN: 1536-5964; 0025-7974; 1536-5964
• DOI: 10.1097/MD.0000000000029961

The present study was conducted to determine the association of transforming growth factor-beta (TGF-β) gene polymorphism and myopia. Four hundred twelve articles were identified, of which 11 articles with 5213 participants in 4 countries were included in the final analysis. Review Manager software (RevMan, version 5.4) was used for data analysis. Odds ratio (OR) value of TGF-β1 rs1800469 is 1.33 (95% confidence interval [CI] = 1.15-1.54) in the allelic model; in the dominant model is 1.76 (95% CI = 1.16-2.67); in homozygous model is 5.98 (95% CI = 4.31-8.06). OR value of TGF-β1 rs4803455 is 0.62 (95% CI = 0.43-0.88) in recessive model. TGF-β2 is not associated with myopia. Relevant study on TGF-β3 is scarce. Our systematic review and meta-analysis found that TGF-β1 rs4803455 and rs1800469 were correlated with myopia.