Advanced glycation end products (AGEs) are cross-sectionally associated with insulin secretion in healthy subjects

• Published in: Amino acids Vol. 46; no. 2; pp. 321 - 326
• Main Authors: Forbes, Josephine M., Sourris, Karly C., de Courten, Maximilian P. J., Dougherty, Sonia L., Chand, Vibhasha, Lyons, Jasmine G., Bertovic, David, Coughlan, Melinda T., Schlaich, Markus P., Soldatos, Georgia, Cooper, Mark E., Straznicky, Nora E., Kingwell, Bronwyn A., de Courten, Barbora
• Format: Journal Article
• Language: English
• Published: Vienna Springer Vienna 01.02.2014; Springer Nature B.V
• Subjects: Adult; advanced glycation end products; Advanced glycosylation end products; Analytical Chemistry; Biochemical Engineering; Biochemistry; Biomedical and Life Sciences; Blood Glucose; body mass index; Chronic exposure; Circulation; Cross-Sectional Studies; dietary nutrient sources; fasting; Female; Glucose; Glucose tolerance; glucose tolerance tests; Glycation End Products, Advanced - blood; Humans; Insulin; Insulin - blood; Insulin - metabolism; Insulin Resistance; Insulin Secretion; Isoforms; Life Sciences; Male; Neurobiology; Original Article; Proteomics; Receptor for Advanced Glycation End Products; Receptors, Immunologic - blood; Young Adult; Type 2 diabetes; Insulin sensitivity; Central obesity; Insulin secretion
• ISSN: 0939-4451; 1438-2199; 1438-2199
• DOI: 10.1007/s00726-013-1542-9

It has been postulated that chronic exposure to high levels of advanced glycation end products (AGEs), in particular from dietary sources, can impair insulin secretion. In the present study, we investigated the cross-sectional relationship between AGEs and acute insulin secretion during an intravenous glucose tolerance test (IVGTT) and following a 75 g oral glucose tolerance test (OGTT) in healthy humans. We report the cross-sectional association between circulating AGE concentrations and insulin secretory function in healthy humans (17 F: 27 M, aged 30 ± 10 years) with a wide range of BMI (24.6–31.0 kg/m 2 ). Higher circulating concentrations of AGEs were related to increased first phase insulin secretion during IVGTT ( r  = 0.43; p  < 0.05) and lower 2-h glucose concentrations during OGTT ( r  = −0.31; p  < 0.05). In addition, fasting ( r  = −0.36; p  < 0.05) and 2-h glucose concentrations were negatively related to circulating levels of soluble receptor for AGE (RAGE) isoforms ( r  = −0.39; p  < 0.01). In conclusion, in healthy humans, we show a cross-sectional association between advanced glycation end products and acute insulin secretion during glucose tolerance testing.