β-3 adrenergic receptor gene polymorphisms are associated with gestational diabetes mellitus in a Chinese population

• Published in: Medicine (Baltimore) Vol. 98; no. 43; p. e17258
• Main Authors: Jia, He, Pan, Yuan, Wang, Yun, Yin, Feng-Ling, Xu, Na
• Format: Journal Article
• Language: English
• Published: United States Wolters Kluwer Health 01.10.2019
• Subjects: Adult; Alleles; Asian Continental Ancestry Group - genetics; Case-Control Studies; Chi-Square Distribution; China; Diabetes, Gestational - genetics; Female; Gene Frequency; Genetic Predisposition to Disease - genetics; Genotype; Humans; Observational Study; Polymorphism, Single Nucleotide - genetics; Pregnancy; Receptors, Adrenergic, beta-3 - genetics; Retrospective Studies; Risk Factors; China
• ISSN: 0025-7974; 1536-5964
• DOI: 10.1097/MD.0000000000017258

Increasing studies demonstrated that genetic susceptibility attributes to the development of gestational diabetes mellitus (GDM). The polymorphisms of the β-3 adrenergic receptor(β-3AR) gene have been found to be of great importance in bodyweight elevation and dyslipidaemias. We aimed to determine the influence of β-3AR polymorphisms on the GDM risk. Thus, we performed a case-control study including 136 GDM cases and 138 controls to evaluate the relation between the rs201607471 and susceptibility to GDM. Likelihood ratios X analysis showed the distribution of the genotype frequency (rs201607471 in β-3AR gene) was accorded with the Hardy-Weinberg genetic equilibrium. Although no significant association between rs201607471 alleles and GDM susceptibility (Chi-square test, P > .05), we observed that β-3AR gene rs201607471 CT genotype was significantly prevalent in GDM (Chi-square test, P < .05). Moreover, we observed that β-3AR gene rs201607471 C > T was significantly associated with an increased risk of GDM using the recessive model (CC vs CT/TT: P = .026) and the additive model (CC vs CT vs TT: P = .038). These data indicate that β-3AR rs201607471 may be a helpful susceptibility marker for GDM in Chinese pregnant women.