Anodic aluminium oxide membranes for immunoisolation with sufficient oxygen supply for pancreatic islets

Immunoisolation membranes have been developed for various cell encapsulations for therapeutic purposes. However effective encapsulation systems have been hindered by low oxygen (O2) permeability or imperfect immunoisolation caused by either low porosity or non-uniform pore geometry. Here, we report...

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Published inIntegrative biology (Cambridge) Vol. 5; no. 5; p. 828
Main Authors Cho, Siwoo, Lee, Sangmin, Jeong, Seong Hee, Kim, Yeongae, Kim, Song Cheol, Hwang, Woonbong, Park, Jaesung
Format Journal Article
LanguageEnglish
Published England 01.05.2013
Subjects
Aluminum Oxide - pharmacology
Animals
Cell Separation - methods
Glucose - metabolism
Insulin - metabolism
Islets of Langerhans - cytology
Islets of Langerhans - metabolism
Islets of Langerhans Transplantation - methods
Membranes, Artificial
Nanotechnology - methods
Oxygen - metabolism
Rats
Rats, Sprague-Dawley
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Summary:Immunoisolation membranes have been developed for various cell encapsulations for therapeutic purposes. However effective encapsulation systems have been hindered by low oxygen (O2) permeability or imperfect immunoisolation caused by either low porosity or non-uniform pore geometry. Here, we report an encapsulation method that uses an anodic aluminum oxide membrane formed by polyethylene oxide self-assembly to obtain nanochannels with both high selectivity in excluding immune molecules and high permeability of nutrients such as glucose, insulin, and O2. The extracorporeal encapsulation system composed of these membranes allows O2 flux to meet the O2 demand of pancreatic islets of Langerhans and provides excellent in vitro viability and functionality of islets.
ISSN:1757-9708
DOI:10.1039/c3ib20226g