Clinical failure among children with nonsevere community-acquired pneumonia treated with amoxicillin

• Published in: Expert opinion on pharmacotherapy Vol. 11; no. 9; p. 1451
• Main Authors: Fontoura, Maria-Socorro H, Araújo-Neto, César A, Andrade, Sandra C S, Brim, Rosa V, Matutino, Adriana R, Silva, Carolina C, Santana, Milena C, Nobre-Bastos, Monalisa, Oliveira, Felipe, Barreto, Bruna B, Santos, Pablo M, Noblat, Lúcia, Cardoso, Maria-Regina A, Nascimento-Carvalho, Cristiana M
• Format: Journal Article
• Language: English
• Published: England 01.06.2010
• Subjects: Amoxicillin - therapeutic use; Anti-Bacterial Agents - therapeutic use; Child, Preschool; Community-Acquired Infections - drug therapy; Humans; Infant; Pneumonia, Bacterial - drug therapy; Treatment Outcome
• ISSN: 1744-7666
• DOI: 10.1517/14656561003777034

To estimate the clinical failure and adverse events in children with nonsevere pneumonia receiving amoxicillin, identifying risk factors. 192 patients aged 2 - 59 months were prospectively followed up. Pneumonia diagnosis was based on respiratory complaints and radiographic pulmonary infiltrate or pleural effusion. Amoxicillin (50 mg/kg/day) was given. Demographic data and clinical findings on admission, daily evolution up to the 5th day of treatment and 2 - 4 weeks after enrollment were collected. Clinical failure included persistence of fever, difficulty breathing or tachypnea beyond the first 48 h of treatment or of cough beyond the first 96 h of treatment or sign of severe/very severe disease up to the 5th day of treatment. Amoxicillin failed in 6 (3.1%) cases. By excluding one child diagnosed with cystic fibrosis after continued follow-up, the final clinical failure rate was 2.6%. The total adverse effect frequency was 14 (7.3%), but amoxicillin was discontinued only in 1 (0.5%) case. No relapse was identified at the 2 - 4-week interval evaluation. By multivariate analysis, age (OR = 1.1; 95% CI 1.01 - 1.19) was an independent risk factor for clinical failure which occurred in older children (47 +/- 9 vs 31 +/- 16 months; p = 0.01). Clinical failures were few, especially among those aged < 2 years. Amoxicillin discontinuation due to adverse reaction was rare.