Altered Amygdala Resting-State Functional Connectivity in Maintenance Hemodialysis End-Stage Renal Disease Patients with Depressive Mood

• Published in: Molecular neurobiology Vol. 54; no. 3; pp. 2223 - 2233
• Main Authors: Chen, Hui Juan, Wang, Yun Fei, Qi, Rongfeng, Schoepf, U. Joseph, Varga-Szemes, Akos, Ball, B. Devon, Zhang, Zhe, Kong, Xiang, Wen, Jiqiu, Li, Xue, Lu, Guang Ming, Zhang, Long Jiang
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.04.2017; Springer Nature B.V
• Subjects: Adolescent; Adult; Amygdala - physiopathology; Biomedical and Life Sciences; Biomedicine; Brain; Brain Mapping; Cell Biology; Depression - psychology; Emotions - physiology; Female; Hemodialysis; Humans; Kidney diseases; Kidney Failure, Chronic - physiopathology; Kidney Failure, Chronic - psychology; Magnetic Resonance Imaging - methods; Male; Mental depression; Middle Aged; Neurobiology; Neurology; Neuropsychological Tests; Neurosciences; NMR; Nuclear magnetic resonance; Renal Dialysis - methods; Young Adult; End-stage renal disease; Resting-state functional connectivity; Amygdala; Magnetic resonance imaging; Hemodialysis
• ISSN: 0893-7648; 1559-1182
• DOI: 10.1007/s12035-016-9811-8

The purpose of this study was to investigate patterns in the amygdala-based emotional processing circuit of hemodialysis patients using resting-state functional MR imaging (rs-fMRI). Fifty hemodialysis patients (25 with depressed mood and 25 without depressed mood) and 26 healthy controls were included. All subjects underwent neuropsychological tests and rs-fMRI, and patients also underwent laboratory tests. Functional connectivity of the bilateral amygdala was compared among the three groups. The relationship between functional connectivity and clinical markers was investigated. Depressed patients showed increased positive functional connectivity of the left amygdala with the left superior temporal gyrus and right parahippocampal gyrus (PHG) but decreased amygdala functional connectivity with the left precuneus, angular gyrus, posterior cingulate cortex (PCC), and left inferior parietal lobule compared with non-depressed patients ( P  < 0.05, AlphaSim corrected). Depressed patients had increased positive functional connectivity of the right amygdala with bilateral supplementary motor areas and PHG but decreased amygdala functional connectivity with the right superior frontal gyrus, superior parietal lobule, bilateral precuneus, and PCC ( P  < 0.05, AlphaSim corrected). After including anxiety as a covariate, we discovered additional decreased functional connectivity with anterior cingulate cortex (ACC) for bilateral amygdala ( P  < 0.05, AlphaSim corrected). For the depressed, neuropsychological test scores were correlated with functional connectivity of multiple regions ( P  < 0.05, AlphaSim corrected). In conclusion, functional connectivity in the amygdala-prefrontal-PCC-limbic circuits was impaired in depressive hemodialysis patients, with a gradual decrease in ACC between controls, non-depressed, and depressed patients for the right amygdala. This indicates that ACC plays a role in amygdala-based emotional regulatory circuits in these patients.