PATTERN OF REDUCTION OF VENTILATORY AND OCCLUSION PRESSURE RESPONSE TO CARBON DIOXIDE BY PENTAZOCINE IN MAN

• Published in: British journal of anaesthesia : BJA Vol. 54; no. 1; pp. 87 - 96
• Main Authors: DRUMMOND, G.B., FISHER, J., ZIDULKA, A., MILIC-EMILI, J.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.01.1982; Oxford University Press
• Subjects: Adult; Carbon Dioxide - physiology; Humans; Male; Naloxone - pharmacology; Pentazocine - pharmacology; Pressure; Pulmonary Ventilation; Respiration - drug effects
• ISSN: 0007-0912; 1471-6771
• DOI: 10.1093/bja/54.1.87

Mean inspiratory flow, occlusion pressure and end-tidal Pco2 were measured in six healthy, sitting subjects, during breathing air and rebreathing carbon dioxide, before and after pentazocine 0.5 mgkg−1 1.v. and again after naloxone 20 μg kg−1. Pentazocine reduced the occlusion pressure and inspiratory flow responses at a given Pco2 during carbon dioxide rebreathing and these effects were antagonized by naloxone. The relationship of inspiratory flow and end-tidal carbon dioxide during rebreathing was used to measure the Pco2 value at which mean inspiratory flow was 1 litre s −1. Occlusion pressure at this Pco2 was reduced in all the subjects by pentazocine, suggesting that the generation of inspiratory flow required less muscle activity This effect was antagonized by naloxone.