Delayed Diagnosis of Falciparum Malaria with Acute Kidney Injury

• Published in: Journal of Korean medical science Vol. 31; no. 9; pp. 1499 - 1502
• Main Authors: Choi, Iee Ho, Hwang, Pyoung Han, Choi, Sam Im, Lee, Dae Yeol, Kim, Min Sun
• Format: Journal Article
• Language: English
• Published: Korea (South) The Korean Academy of Medical Sciences 01.09.2016; 대한의학회
• Subjects: Acute Kidney Injury - complications; Adolescent; Case Report; Delayed Diagnosis; DNA, Protozoan - analysis; Glomerular Filtration Rate; Humans; Malaria, Falciparum - complications; Malaria, Falciparum - diagnosis; Malaria, Falciparum - parasitology; Male; Plasmodium falciparum - genetics; Plasmodium falciparum - isolation & purification; Polymerase Chain Reaction; Renal Dialysis; 의학일반; Renal Failure; Plasmodium falciparum; Diagnosis; Malaria; Dialysis, Plasmapheresis
• ISSN: 1011-8934; 1598-6357
• DOI: 10.3346/jkms.2016.31.9.1499

Prompt malaria diagnosis is crucial so antimalarial drugs and supportive care can then be rapidly initiated. A 15-year-old boy who had traveled to Africa (South Africa, Kenya, and Nigeria between January 3 and 25, 2011) presented with fever persisting over 5 days, headache, diarrhea, and dysuria, approximately 17 days after his return from the journey. Urinalysis showed pyuria and hematuria. Blood examination showed hemolytic anemia, thrombocytopenia, disseminated intravascular coagulation, and hyperbilirubinemia. Plasmapheresis and hemodialysis were performed for 19 hospital days. Falciparum malaria was then confirmed by peripheral blood smear, and antimalarial medications were initiated. The patient's condition and laboratory results were quickly normalized. We report a case of severe acute renal failure associated with delayed diagnosis of falciparum malaria, and primary use of supportive treatment rather than antimalarial medicine. The present case suggests that early diagnosis and treatment is important because untreated tropical malaria can be associated with severe acute renal failure and fatality. Physicians must be alert for correct diagnosis and proper management of imported tropical malaria when patients have travel history of endemic areas.