Prevalence of RET/PTC Rearrangements in Hashimoto's Thyroiditis and Papillary Thyroid Carcinomas

The relationship between Hashimoto's thyroiditis (HT) and follicular cell-derived thy roid cancer remains unclear. Recently, 2 studies reported a 95% prevalence of RET/PTC rearrangements in histologically benign tissue affected by HT, suggesting that multiple occult tumors exist in HT patients...

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Bibliographic Details
Published inInternational journal of surgical pathology Vol. 10; no. 1; pp. 15 - 22
Main Authors Nikiforova, Marina N., Caudill, Christy M., Biddinger, Paul, Nikiforov, Yuri E.
Format Journal Article
LanguageEnglish
Published Los Angeles, CA SAGE Publications 01.01.2002
Subjects
Carcinoma, Papillary, Follicular - complications
Carcinoma, Papillary, Follicular - genetics
Frozen Sections
Gene Rearrangement
Humans
Oncogene Proteins, Fusion - analysis
Paraffin Embedding
Proto-Oncogene Proteins - analysis
Proto-Oncogene Proteins - genetics
Proto-Oncogene Proteins c-ret
Receptor Protein-Tyrosine Kinases - analysis
Receptor Protein-Tyrosine Kinases - genetics
Reverse Transcriptase Polymerase Chain Reaction
RNA, Messenger - analysis
Thyroid Neoplasms - complications
Thyroid Neoplasms - genetics
Thyroiditis, Autoimmune - complications
Thyroiditis, Autoimmune - genetics
thyroid
RET gene
Hashimito's thyroiditis
papillary carcinoma
RET/PTC rearrangement
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Summary:The relationship between Hashimoto's thyroiditis (HT) and follicular cell-derived thy roid cancer remains unclear. Recently, 2 studies reported a 95% prevalence of RET/PTC rearrangements in histologically benign tissue affected by HT, suggesting that multiple occult tumors exist in HT patients with high frequency. We tested the prevalence of RET/PTC rearrangements in 26 HT, in 6 papillary carcinomas arising in the background of HT, and in 27 papillary carcinomas not associated with HT. We detected no RET/PTC rearrangements in HT or papillary carcinomas arising in the background of HT, in contrast to a 33% prevalence among papillary carcinomas not associated with HT. However, the expression of wild-type RET was found in more than half of papillary carcinomas. These results suggest that, if the association be tween HT and thyroid cancer exists, its molecular basis is different from RETIPTC rearrangement. Int J Surg Pathol 10(1):15-22, 2002
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ISSN:1066-8969
1940-2465
DOI:10.1177/106689690201000104