Visual Motion and Form Integration in the Behaving Ferret

• Published in: eNeuro Vol. 6; no. 4; p. ENEURO.0228-19.2019
• Main Authors: Dunn-Weiss, Erika, Nummela, Samuel U, Lempel, Augusto A, Law, Jody M, Ledley, Johanna, Salvino, Peter, Nielsen, Kristina J
• Format: Journal Article
• Language: English
• Published: United States Society for Neuroscience 01.07.2019
• Subjects: Animals; Discrimination, Psychological - physiology; Female; Ferrets - physiology; Ferrets - psychology; Form Perception - physiology; Male; Motion Perception - physiology; Neurons - physiology; New Research; Photic Stimulation; Psychophysics; ROC Curve; Sensory Thresholds - physiology; Visual Cortex - physiology; Visual Pathways - physiology; electrophysiology; behavior; form vision; visual cortex; ferret; motion vision
• ISSN: 2373-2822; 2373-2822
• DOI: 10.1523/ENEURO.0228-19.2019

Ferrets have become a standard animal model for the development of early visual stages. Less is known about higher-level vision in ferrets, both during development and in adulthood. Here, as a step towards establishing higher-level vision research in ferrets, we used behavioral experiments to test the motion and form integration capacity of adult ferrets. Motion integration was assessed by training ferrets to discriminate random dot kinematograms (RDK) based on their direction. Task difficulty was varied systematically by changing RDK coherence levels, which allowed the measurement of motion integration thresholds. Form integration was measured analogously by training ferrets to discriminate linear Glass patterns of varying coherence levels based on their orientation. In all experiments, ferrets proved to be good psychophysical subjects that performed tasks reliably. Crucially, the behavioral data showed clear evidence of perceptual motion and form integration. In the monkey, motion and form integration are usually associated with processes occurring in higher-level visual areas. In a second set of experiments, we therefore tested whether PSS, a higher-level motion area in the ferret, could similarly support motion integration behavior in this species. To this end, we measured responses of PSS neurons to RDK of different coherence levels. Indeed, neurometric functions for PSS were in good agreement with the behaviorally derived psychometric functions. In conclusion, our experiments demonstrate that ferrets are well suited for higher-level vision research.