The number of stents was an independent risk of stent restenosis in patients undergoing percutaneous coronary intervention

• Published in: Medicine (Baltimore) Vol. 98; no. 50; p. e18312
• Main Authors: Tang, Long, Cui, Qian-Wei, Liu, Dan-Ping, Fu, Ying-Ying
• Format: Journal Article
• Language: English
• Published: United States Wolters Kluwer Health 01.12.2019
• Subjects: China - epidemiology; Coronary Angiography; Coronary Artery Disease - surgery; Coronary Restenosis - epidemiology; Coronary Restenosis - etiology; Coronary Vessels - diagnostic imaging; Coronary Vessels - surgery; Female; Follow-Up Studies; Humans; Incidence; Male; Middle Aged; Observational Study; Percutaneous Coronary Intervention - methods; Retrospective Studies; Risk Factors; Stents - statistics & numerical data; China
• ISSN: 0025-7974; 1536-5964
• DOI: 10.1097/MD.0000000000018312

Percutaneous coronary intervention (PCI) is one of the most effective therapies for coronary artery disease, but stent restenosis remains an important clinical challenge. The studies about the independent effect of the number of stents on stent restenosis were limited.The purpose was to identify the independent effect of the number of stents on stent restenosis.A retrospective cohort study of data reuse.From July 2009 to August 2011, a total of 2338 cases met the inclusion and exclusion criteria.The univariate analysis showed that the number of stents was a risk of stent restenosis, the OR value was 1.30 (95% CI:1.15 to 1.47, P < .001). The multi-factor regression analysis also showed that the number of stents was an independent risk of stent restenosis, the adjusted OR value was 1.38 (95% CI: 1.15 to 1.66, P < .001).Compared with 1-2 stents, the adjusted OR values of 3-5 stents and more than 6 stents were respectively 2.20 (95% CI: 1.24 to 3.90, P = .007) and 5.33 (95% CI: 1.89 to 15.08, P = .002), and the trend adjusted OR values was 2.26 (95% CI: 1.43 to 3.59, P < .001).The subgroup analysis of multi-factor regression analysis showed that when patients with the following conditions: 50 < Age, female, non-DES or SES, the risk of stent restenosis increased obviously.The number of stents was an independent risk of stent restenosis in patients undergoing PCI, especially for patients with the following conditions: 2<the number of stents, 50 < age, female, Non-DES (Drug-eluting stents) or SES (sirolimus-eluting stent).