Understanding the role of inflammatory cytokines in malaria and related diseases
Summary It is now broadly accepted for infectious disease in general that it is not the invading organism, but the body's unbridled response to it—the “cytokine storm”—that causes illness and pathology. Nevertheless, many researchers still regard the harmful effects of falciparum malaria as bei...
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Published in | Travel medicine and infectious disease Vol. 6; no. 1; pp. 67 - 81 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Netherlands
Elsevier Ltd
01.01.2008
Elsevier Limited |
Subjects | |
Online Access | Get full text |
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Summary: | Summary It is now broadly accepted for infectious disease in general that it is not the invading organism, but the body's unbridled response to it—the “cytokine storm”—that causes illness and pathology. Nevertheless, many researchers still regard the harmful effects of falciparum malaria as being governed by oligaemic hypoxia arising from parasitised erythrocytes obstructing blood flow through vulnerable organs, particularly the brain, and we summarise why these notions are no longer tenable. In our view, this harmful sequestration is readily accommodated within the cytokine storm perspective as one of its secondary effects. We approach these issues by examining aspects of malaria, sepsis and influenza in parallel, and discuss the insights that comparisons of the literature can provide on the validity of possible anti-disease therapies. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 |
ISSN: | 1477-8939 1873-0442 |
DOI: | 10.1016/j.tmaid.2007.07.002 |