Serum metabolic profile predicts adverse central haemodynamics in patients with type 2 diabetes mellitus

• Published in: Acta diabetologica Vol. 53; no. 3; pp. 367 - 375
• Main Authors: Nikolic, Sonja B., Edwards, Lindsay M., Karpievitch, Yuliya V., Wilson, Richard, Horne, James, Adams, Murray J., Sharman, James E.
• Format: Journal Article
• Language: English
• Published: Milan Springer Milan 01.06.2016; Springer Nature B.V
• Subjects: Aged; Blood pressure; Diabetes; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - physiopathology; Exercise; Female; Hemodynamics; Humans; Internal Medicine; Male; Mass spectrometry; Medicine; Medicine & Public Health; Metabolic Diseases; Metabolism; Metabolome; Middle Aged; NMR; Nuclear magnetic resonance; Original Article; Metabolomics; Nuclear magnetic resonance spectroscopy; Blood pressure; Exercise; Liquid chromatography–mass spectrometry
• ISSN: 0940-5429; 1432-5233
• DOI: 10.1007/s00592-015-0802-4

Aims People with type 2 diabetes mellitus (T2DM) have abnormal peripheral and central haemodynamics at rest and during exercise, probably due to metabolic perturbations, but mechanisms are unknown. We used untargeted metabolomics to determine the relationships between metabolic perturbations and haemodynamics (peripheral and central) measured at rest and during exercise. Methods Serum samples from 39 participants with T2DM (62 ± 9 years; 46 % male) and 39 controls (52 ± 10 years; 51 % male) were analysed by liquid chromatography–mass spectrometry, nuclear magnetic resonance spectroscopy and principal component analysis. Scores on principal components (PC) were used to assess relationships with haemodynamics including peripheral and central BP, central augmentation index (AIx) and central augmentation pressure (AP). Results Participants with T2DM had higher resting and exercise haemodynamics (peripheral and central BP, central AIx and central AP) compared to controls ( p  < 0.05). PC that comprised of a signature metabolic pattern of T2DM was independently associated with resting and exercise central AIx and central AP ( p  < 0.05). Conclusions Serum metabolic profile was associated with central, but not peripheral, haemodynamics in T2DM participants, suggesting that metabolic irregularities may explain abnormal central haemodynamics in T2DM patients.