Emerging role of adipokines in systemic lupus erythematosus

Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder characterized by multisystem organ involvement and unclear pathogenesis. Several adipokines synthesized in the adipose tissue, including leptin, adiponectin, resistin, and chemerin, have been explored in autoimmune rheumatic disease...

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Published inImmunologic research Vol. 64; no. 4; pp. 820 - 830
Main Authors Li, Hong-Miao, Zhang, Tian-Ping, Leng, Rui-Xue, Li, Xiang-Pei, Li, Xiao-Mei, Liu, Hai-Rong, Ye, Dong-Qing, Pan, Hai-Feng
Format Journal Article
LanguageEnglish
Published New York Springer US 01.08.2016
Springer Nature B.V
Subjects
Adipokines - immunology
Adipokines - metabolism
Adiponectin - metabolism
Adipose Tissue - immunology
Allergology
Animals
Biomedical and Life Sciences
Biomedicine
Chemokines - metabolism
Cytokines
Humans
Immune system
Immunology
Intercellular Signaling Peptides and Proteins - metabolism
Internal Medicine
Leptin - metabolism
Lupus
Lupus Erythematosus, Systemic - immunology
Lupus Erythematosus, Systemic - therapy
Medicine/Public Health
Molecular Targeted Therapy
Pathogenesis
Resistin - metabolism
Review
Systemic lupus erythematosus
Adipokines
Leptin
Adiponectin
Resistin
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Summary:Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder characterized by multisystem organ involvement and unclear pathogenesis. Several adipokines synthesized in the adipose tissue, including leptin, adiponectin, resistin, and chemerin, have been explored in autoimmune rheumatic diseases, especially SLE, and results suggest that these mediators may be implicated in the pathogenesis of SLE. However, the current results are controversial. In this review, we will briefly discuss the expression and possible pathogenic role of several important adipokines, including leptin, adiponectin, resistin, and chemerin in SLE.
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ISSN:0257-277X
1559-0755
DOI:10.1007/s12026-016-8808-8