Usefulness of three-dimensional navigable intraoperative ultrasound in resection of brain tumors with a special emphasis on malignant gliomas

• Published in: Acta neurochirurgica Vol. 155; no. 12; pp. 2217 - 2225
• Main Authors: Moiyadi, Aliasgar V., Shetty, Prakash M., Mahajan, Abhishek, Udare, Amar, Sridhar, Epari
• Format: Journal Article
• Language: English
• Published: Vienna Springer Vienna 01.12.2013; Springer Nature B.V
• Subjects: Angiography; Brain Neoplasms - diagnostic imaging; Brain Neoplasms - pathology; Brain Neoplasms - surgery; Clinical Article - Brain Tumors; Databases, Factual; Glioma - diagnostic imaging; Glioma - pathology; Glioma - surgery; Humans; Imaging, Three-Dimensional - methods; Interventional Radiology; Medicine; Medicine & Public Health; Minimally Invasive Surgery; Monitoring, Intraoperative - methods; Neurology; Neuronavigation - methods; Neuroradiology; Neurosurgery; Neurosurgical Procedures - methods; Prospective Studies; Surgical Orthopedics; Ultrasonography; Navigable ultrasound; Image-guided surgery; Intraoperative ultrasound; Sononavigation; Brain tumors
• ISSN: 0001-6268; 0942-0940; 0942-0940
• DOI: 10.1007/s00701-013-1881-z

Background Intraoperative imaging is increasingly being used in resection of brain tumors. Navigable three-dimensional (3D)-ultrasound is a novel tool for planning and guiding such resections. We review our experience with this system and analyze our initial results, especially with respect to malignant gliomas. Methods A prospective database for all patients undergoing sononavigation-guided surgery at our center since this surgery’s introduction in June 2011 was queried to retrieve clinical data and technical parameters. Imaging was reviewed to categorize tumors based on enhancement and resectability. Extent of resection was also assessed. Results Ninety cases were operated and included in this analysis, 75 % being gliomas. The 3D ultrasound mode was used in 87 % cases (alone in 40, and combined in 38 cases). Use of combined mode function [ultrasound (US) with magnetic resonance (MR) images] facilitated orientation of anatomical data. Intraoperative power Doppler angiography was used in one-third of the cases, and was extremely beneficial in delineating the vascular anatomy in real-time. Mean duration of surgery was 4.4 hours. Image resolution was good or moderate in about 88 % cases. The use of the intraoperative imaging prompted further resection in 59 % cases. In the malignant gliomas (51 cases), gross-total resection was achieved in 47 % cases, increasing to 88 % in the “resectable” subgroup. Conclusions Navigable 3D US is a versatile, useful and reliable intraoperative imaging tool in resection of brain tumors, especially in resource-constrained settings where Intraoperative MR (IOMR) is not available. It has multiple functionalities that can be tailored to suit the procedure and the experience of the surgeon.