Extracranial-Intracranial Bypass for Stroke—Is This the End of the Line or a Bump in the Road?

• Published in: Neurosurgery Vol. 71; no. 3; pp. 557 - 561
• Main Authors: AMIN-HANJANI, Sepideh, BARKER, Fred G, CHARBEL, Fady T, SANDER CONNOLLY, E, MORCOS, Jacques J, GREGORY THOMPSON, B
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Oxford University Press 01.09.2012; Lippincott Williams & Wilkins; Wolters Kluwer Health, Inc
• Subjects: Biological and medical sciences; Carotid Artery Diseases - surgery; Cerebral Revascularization - methods; Humans; Medical sciences; Neurosurgery; Stroke - surgery; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Carotid occlusion; Extracranial-intracranial bypass; Stroke; Intracranial; Nervous system diseases; Cardiovascular disease; Extracranial; Cerebral disorder; Vascular disease; Bypass; Carotid; Surgery; Central nervous system disease; Cerebrovascular disease
• ISSN: 0148-396X; 1524-4040
• DOI: 10.1227/NEU.0b013e3182621488

Abstract The results of the recently published Carotid Occlusion Surgery Study, which failed to show a benefit of extracranial-intracranial (EC-IC) bypass over medical therapy in patients with symptomatic hemodynamically significant carotid occlusion, have been interpreted by some as the end of the line for EC-IC bypass in the management of stroke. Despite being carefully conceived and executed, several aspects of the trial design, study population, and underlying assumptions deserve further examination to determine how best to translate these results into clinical practice. Although a general expansion of EC-IC bypass use in this population would not be supported by the trial results, a select subset of patients with medically refractory hemodynamic symptoms may well benefit from surgery performed with sufficiently low perioperative morbidity. The potential for beneficial functional or cognitive impact of revascularization also remains under investigation. Limited application and further study with an eye to future developments, rather than complete abandonment, is warranted.