Embryo bioassays with aquatic animals for toxicity testing and hazard assessment of emerging pollutants: A review

This review article gathers the available information on the use of embryo-tests as high-throughput tools for toxicity screening, hazard assessment and prioritization of new and existing chemical compounds. The approach is contextualized considering the new legal trends for animal experimentation, f...

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Bibliographic Details
Published inThe Science of the total environment Vol. 705; p. 135740
Main Authors Capela, Ricardo, Garric, Jeanne, Castro, Luís Filipe Costa, Santos, Miguel Machado
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 25.02.2020
Elsevier
Subjects
Animals
Biodiversity
Biological Assay
Ecology, environment
Ecosystem
Embryo-bioassay
Environmental Pollutants
Life Sciences
Molecular resources
Risk Assessment
Toxicity test
Toxicity Tests
Molecular resources
Toxicity test
Biodiversity
Embryo-bioassay
Risk assessment
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Summary:This review article gathers the available information on the use of embryo-tests as high-throughput tools for toxicity screening, hazard assessment and prioritization of new and existing chemical compounds. The approach is contextualized considering the new legal trends for animal experimentation, fostering the 3R policy, with reduction of experimental animals, addressing the potential of embryo-tests as high-throughput toxicity screening and prioritizing tools. Further, the current test guidelines, such as the ones provided by OECD and EPA, focus mainly in a limited number of animal lineages, particularly vertebrates and arthropods. To extrapolate hazard assessment to the ecosystem scale, a larger diversity of taxa should be tested. The use of new experimental animal models in toxicity testing, from a representative set of taxa, was thoroughly revised and discussed in this review. Here, we critically review current tools and the main advantages and drawbacks of different animal models and set researcher priorities. [Display omitted] •Embryo-tests as high-throughput tools for toxicity screening•Hazard assessment and prioritization of new and existing chemical compounds•Novel experimental animal models in toxicity testing•Large set of available resources for the standardization of embryo-tests
ISSN:0048-9697
1879-1026
DOI:10.1016/j.scitotenv.2019.135740