Association between IL-4 -589C>T polymorphism and colorectal cancer risk

• Published in: Tumor biology Vol. 35; no. 3; pp. 2675 - 2679
• Main Authors: Li, Qiang, Wang, Qian, Xu, Xiaoyan, Ren, Songtao, Wang, Li
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01.03.2014; Springer Nature B.V
• Subjects: Biomedical and Life Sciences; Biomedicine; Cancer Research; Case-Control Studies; Colorectal cancer; Colorectal Neoplasms - genetics; Cytokines; Epidemiology; Genetic Predisposition to Disease - genetics; Humans; Interleukin-4 - genetics; Meta-analysis; Odds Ratio; Polymorphism, Single Nucleotide - genetics; Research Article; Risk assessment; Risk Factors; Interleukin-4; Risk; Colorectal cancer; Meta-analysis
• ISSN: 1010-4283; 1423-0380
• DOI: 10.1007/s13277-013-1352-4

In order to make a comprehensive assessment of the potential association between interleukin-4 (IL-4) -589C>T and colorectal cancer (CRC) susceptibility, we conducted a meta-analysis of six epidemiological studies, which included 1,317 CRC patients and 1,659 controls. The data showed that IL-4 -589C>T was not associated with increased CRC risk in the overall population. In the subgroup analysis of IL-4 -589C>T, the results did not change when the analyses were restricted to race. Based on this meta-analysis, we conclude that IL-4 -589C>T may be not a risk factor for CRC development. Further research is needed to assess possible gene–gene or gene–environment–lifestyle interactions on CRC.