Duodenal infusion of fat, cholecystokinin secretion and satiety in the pig

• Published in: Physiology & behavior Vol. 45; no. 5; p. 1021
• Main Authors: Gregory, P.C. (The Rowett Research Institute, Bucksburn, Aberdeen), McFadyen, M, Rayner, D.V
• Format: Journal Article
• Language: English
• Published: United States 01.05.1989
• Subjects: Animals; APETITO; APPETIT; APPETITE; BARLEY; Benzodiazepinones - pharmacology; CEBADA; CERDO; Cholecystokinin - antagonists & inhibitors; Cholecystokinin - metabolism; Cholecystokinin - physiology; CORPS GRAS; Devazepide; DIET; DIETA; Dose-Response Relationship, Drug; Duodenum; Eating - drug effects; Fat Emulsions, Intravenous - administration & dosage; Fat Emulsions, Intravenous - pharmacology; FATS; FOOD INTAKE; Glucose - pharmacology; Glycerides - pharmacology; Glycerol - pharmacology; GRASAS; HORMONAS; HORMONE; HORMONES; INGESTION DE ALIMENTOS; INTESTIN; INTESTINES; INTESTINOS; Oleic Acids - pharmacology; ORGE; Parenteral Nutrition; PORCIN; PRISE ALIMENTAIRE; REGIME ALIMENTAIRE; Satiation - drug effects; SECRECION; SECRETION; Sincalide - pharmacology; SWINE
• ISSN: 0031-9384; 1873-507X
• DOI: 10.1016/0031-9384(89)90232-1

The influence of the cholecystokinin (CCK) antagonist L-364,718 (0.1 mg/kg) on short-term control of food intake was studied in 6 pigs. Arterial injection of L-364,718 abolished the inhibition of intake to CCK octapeptide infusion (4 micrograms/kg/hr; from 42% p less than 0.001, to 97% of control intake), but did not alter control intake (99%). Injection of L-364,718 also abolished the inhibition of intake to duodenal infusion of emulsified fat (12 g/hr; from 76% p less than 0.001 to 105%) and of monoglyceride (24 g/hr; from 64% p less than 0.001 to 101%), but did not alter the inhibition to oleic acid (60 g/hr; 48% p less than 0.01 and 61% p less than 0.02), to glycerol (127 g/hr; 84% p less than 0.05 and 89%) or to glucose (144 g/hr; 78% p less than 0.02 and 69% p less than 0.001). These results suggest that monoglyceride-induced CCK secretion is mainly responsible for the satiety to duodenal fat in the pig, but that there is also a CCK-independent effect via the fatty acid. The results further indicate that intake of a normal barley-based diet (2% fat) is controlled via CCK-independent mechanisms.