Chemical control of adaptive function of plant pathogenic fungi

• Published in: Doklady. Biochemistry and biophysics Vol. 461; no. 1; pp. 69 - 71
• Main Authors: Khomutov, R. M., Khurs, E. N., Osipova, T. I., Zhemchuzhina, N. S., Mikituk, O. D., Nazarova, T. A., Shcherbakova, L. A., Dzhavakhiya, V. G.
• Format: Journal Article
• Language: English
• Published: Moscow Pleiades Publishing 01.03.2015; Springer Nature B.V
• Subjects: Acetyl Coenzyme A - metabolism; Adaptation, Physiological - drug effects; Adaptation, Physiological - physiology; Ascomycota; Biochemistry; Biological and Medical Physics; Biomedical and Life Sciences; Biophysics; Biophysics and Molecular Biology; Chemotherapy; Fungal Proteins - metabolism; Fungi; Fungicides, Industrial - pharmacology; Fusarium; Infections; Life Sciences; Pathogens; Studies; Triazoles - pharmacology; Tebucona Zole; Pathogenic Fungus; Phosphonic Acid; DOKLADY Biochemistry; Adaptive Function
• ISSN: 1607-6729; 1608-3091
• DOI: 10.1134/S1607672915020015

Development of resistance of pathogenic fungi to fungicides is a problem of general importance. Its solution requires not only intensification of the exist ing system of creation of fungicides, but also the necessity to develop new approaches to chemotherapy of fungal infections. In this regard, the search for methods to increase the sensitivity of pathogenic fungi to fungicides using compounds (sensitizers) weaken ing the protective functions of pathogens may be of particular interest, because the use of such com pounds would make it possible to retain the possibility of effective application of well studied fungicides. One of the few examples of implementing this approach is the use of sensitizers, which were found in a series of natural phenolic compounds and whose target is the fungal antioxidant system]. Similarly, it was found that the activity of synthetic D octapeptide derivative and natural sterols was associated with the inhibition of transmembrane transport sys tems. The use of such compounds made it possible to reduce the resistance of pathogenic fungi, making the known fungicides effective. It is obvious that the development of this trend significantly depends on the solution of the problem of creating new chemical sensitizers.