Molecular Cloning and Tissue Expression of Human Mitochondrial 3-Hydroxy-3-Methylglutaryl-CoA Synthase

• Published in: Archives of biochemistry and biophysics Vol. 317; no. 2; pp. 385 - 390
• Main Authors: Mascaro, C., Buesa, C., Ortiz, J.A., Hare, D., Hegardt, F.G.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 10.03.1995
• Subjects: Amino Acid Sequence; Animals; Base Sequence; Cloning, Molecular; Colon - enzymology; DNA, Complementary - chemistry; DNA, Complementary - isolation & purification; Gene Expression; Humans; Hydroxymethylglutaryl-CoA Synthase - genetics; Mitochondria, Liver - enzymology; Molecular Sequence Data; Organ Specificity; Rats; Restriction Mapping

Mitochondrial 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) synthase is a constituent of the HMG-CoA pathway responsible for ketone body synthesis and one of its main regulatory points. We report the isolation and characterization of a 2058-bp cDNA from human liver. This cDNA encodes a polypeptide...