Aminoglycosides: An Overview

Aminoglycosides are natural or semisynthetic antibiotics derived from actinomycetes. They were among the first antibiotics to be introduced for routine clinical use and several examples have been approved for use in humans. They found widespread use as first-line agents in the early days of antimicr...

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Published inCold Spring Harbor perspectives in medicine Vol. 6; no. 6; p. a027029
Main Authors Krause, Kevin M., Serio, Alisa W., Kane, Timothy R., Connolly, Lynn E.
Format Journal Article
LanguageEnglish
Published United States Cold Spring Harbor Laboratory Press 01.06.2016
Subjects
Aminoglycosides - pharmacology
Anti-Bacterial Agents - pharmacology
Drug Design
Drug Resistance, Multiple, Bacterial
Humans
RNA, Ribosomal, 16S - metabolism
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Summary:Aminoglycosides are natural or semisynthetic antibiotics derived from actinomycetes. They were among the first antibiotics to be introduced for routine clinical use and several examples have been approved for use in humans. They found widespread use as first-line agents in the early days of antimicrobial chemotherapy, but were eventually replaced in the 1980s with cephalosporins, carbapenems, and fluoroquinolones. Aminoglycosides synergize with a variety of other antibacterial classes, which, in combination with the continued increase in the rise of multidrug-resistant bacteria and the potential to improve the safety and efficacy of the class through optimized dosing regimens, has led to a renewed interest in these broad-spectrum and rapidly bactericidal antibacterials.
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ISSN:2157-1422
2472-5412
DOI:10.1101/cshperspect.a027029