Antileishmanial activities associated with plants used in the Malian traditional medicine

• Published in: Journal of ethnopharmacology Vol. 110; no. 1; pp. 99 - 104
• Main Authors: Ahua, Kouassi Maximin, Ioset, Jean-Robert, Ioset, Karine Ndjoko, Diallo, Drissa, Mauël, Jacques, Hostettmann, Kurt
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 01.03.2007; Elsevier
• Subjects: Anti-Infective Agents; Antileishmanial activity; antiprotozoal agents; Biological and medical sciences; Bobgunnia madagascarensis; cutaneous leishmaniasis; Entada africana; ethnobotany; General pharmacology; herbal medicines; Leishmania major; Mali; Medical sciences; medicinal plants; medicinal properties; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Plant extracts; Pseudocedrela kotschyi; Psorospermum guineense; Sarcocephalus latifolius; Traditional medicine; Zanthoxylum zanthoxyliodes; Mali; Africa; FN; FP; Traditional medicine; DCM; Plant extracts; H 2O; MeOH; Mali; TM; HAT; TN; WHO/TDR; TP; Antileishmanial activity; Leishmania major; Kinetoplastida; Protozoa; Folk medicine; Pharmacognosy; Plant origin; Parasiticide; Medicinal plant
• ISSN: 0378-8741; 1872-7573
• DOI: 10.1016/j.jep.2006.09.030

Sixty-four extracts issued from twenty-one plants used in the Malian traditional medicine – several of them as antiparasitic drugs – were assayed for their antileishmanial effects against both extracellular and intracellular forms of Leishmania major. Seven extracts from six different plants – Sarcocephalus latifolius, Zanthoxylum zanthoxyloides, Entada africana, Bobgunnia madagascarensis, Pseudocedrela kotschyi and Psorospermum guineense – were found to be significantly active against the intracellular form of the parasite.