A highly efficient and catalytic synthetic protocol for oxathioacetalization of carbonyl compounds
A variety of aldehydes and ketones can be converted easily to the corresponding 1,3-oxathiolane derivatives, on treating with 2-mercaptoethanol using a catalytic amount of bromodimethylsulfonium bromide as pre-catalyst at room temperature under solvent-free conditions. Some of the major privileges a...
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Published in | Journal of molecular catalysis. A, Chemical Vol. 226; no. 2; pp. 207 - 212 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Amsterdam
Elsevier B.V
15.02.2005
Elsevier |
Subjects | |
Online Access | Get full text |
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Summary: | A variety of aldehydes and ketones can be converted easily to the corresponding 1,3-oxathiolane derivatives, on treating with 2-mercaptoethanol using a catalytic amount of bromodimethylsulfonium bromide as pre-catalyst at room temperature under solvent-free conditions. Some of the major privileges are: mild reaction conditions, high yields, no aqueous work-up and no chromatographic separation; which is highly economic and compatible in the presence of other protecting groups. Furthermore, no brominations occur either at the double bond or α to the keto position and even in the aromatic ring. |
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ISSN: | 1381-1169 1873-314X |
DOI: | 10.1016/j.molcata.2004.10.019 |