Hymenolepis microstoma: Mouse strain differences in resistance to a challenge infection

• Published in: Experimental parasitology Vol. 58; no. 3; pp. 325 - 332
• Main Authors: Murray, Peter D., Foster, William B., Passmore, Howard C.
• Format: Journal Article
• Language: English
• Published: San Diego, CA Elsevier Inc 01.12.1984; Elsevier
• Subjects: ACTIVE IMMUNIZATION; Animals; Antibody; Antibody Formation; Biological and medical sciences; Cestode; Diseases caused by cestodes; Female; Helminthic diseases; Hymenolepiasis - immunology; HYMENOLEPIS; Hymenolepis - immunology; HYMENOLEPIS MICROSTOMA; IgA; IMMUNITE; IMMUNITY; Immunity, Active; Immunity, Innate; Immunization; Immunoglobulin A - biosynthesis; IMMUNOGLOBULINE; IMMUNOGLOBULINS; Infectious diseases; INMUNIDAD; INMUNOGLOBULINA; intestinal; Intestines - immunology; Lipopolysaccharides - pharmacology; Medical sciences; MICE; Mice, Inbred AKR; Mice, Inbred C3H; Mice, Inbred Strains; Mouse strain; Mouse variation; Parasitic diseases; PEST RESISTANCE; Protection; RATON; RESISTANCE AUX RAVAGEURS; RESISTENCIA A LAS PLAGAS; SOURIS; Species Specificity; STRAIN DIFFERENCES; Taeniases; Tapeworm; Tropical medicine; Tapeworm; intestinal; IgA; Immunization; Antibody; Mouse variation; Cestode; Mouse strain; Hymenolepis microstoma; Protection; Cestod disease; Infection; Vertebrata; Experimental disease; Mammalia; Mouse; Pathogenesis; Animal; Rodentia; Teniasis; Helminthiasis
• ISSN: 0014-4894; 1090-2449
• DOI: 10.1016/0014-4894(84)90049-3

Antibody responses and host resistance to the tapeworm, Hymenolepis microstoma, were investigated using AKR J and C3 HeB FeJ strains of mice. AKR mice were significantly more resistant than controls to a secondary infection following exposure to a 3-, 21-, or 40-day primary infection. During a primary infection, intestinal anti-worm antibody responses measured by an enzyme-linked immunosorbent assay were elevated in the more resistant AKR strain, whereas serum antibody titers did not differ between the two strains. However, during a secondary infection, serum IgA titers were higher in AKR mice than C3H mice. Suppression of the serum IgA anti-worm response by oral administration of lipopolysaccharide also suppressed resistance to a secondary infection. Intraperitoneal immunization with worm antigen resulted in a minor degree of protection in AKR mice. This protection was associated with increased intestinal antibody titers compared to mice not demonstrating protection. These results suggest that the protective responses observed in AKR mice relative to C3H mice reflect differences in mucosal antibody responses to H. microstoma.