The defense response of Caenorhabditis elegans to Cutibacterium acnes SK137 via the TIR-1-p38 MAPK signaling pathway

Cutibacterium acnes plays roles in both acne disease and healthy skin ecosystem. We observed that mutations in the tir-1/SARM1 and p38 MAPK cascade genes significantly shortened Caenorhabditis elegans lifespan upon C. acnes SK137 infection. Antimicrobial molecules were induced by SK137 in a TIR-1-de...

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Published inBioscience, biotechnology, and biochemistry Vol. 86; no. 3; pp. 374 - 379
Main Authors Tsuru, Ayano, Hamazaki, Yumi, Tomida, Shuta, Ali, Mohammad Shaokat, Kage-Nakadai, Eriko
Format Journal Article
LanguageEnglish
Published England Oxford University Press 24.02.2022
Subjects
Animals
Caenorhabditis elegans
antimicrobial molecule
Caenorhabditis elegans
Cutibacterium acnes
tir-1
p38 MAPK
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Summary:Cutibacterium acnes plays roles in both acne disease and healthy skin ecosystem. We observed that mutations in the tir-1/SARM1 and p38 MAPK cascade genes significantly shortened Caenorhabditis elegans lifespan upon C. acnes SK137 infection. Antimicrobial molecules were induced by SK137 in a TIR-1-dependent manner. These results suggest that defense responses against SK137 involve the TIR-1-p38 MAPK pathway in C. elegans.
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These authors contributed equally to this work.
ISSN:1347-6947
0916-8451
1347-6947
DOI:10.1093/bbb/zbab218