Studies of bone tissue in rats treated by prednisolone and 1,25-(OH)2D3

Adult male rats were treated for six weeks by prednisolone and/or 1,25-(OH)2D3 and given a diet containing either 0.5% calcium or 0.01% Ca and 0.6% phosphorus. Both prednisolone administration and a low-Ca diet were associated with a lower bone mass than that observed in control rats given a 0.5% Ca...

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Bibliographic Details
Published inClinical orthopaedics and related research no. 181; p. 264
Main Authors Lindgren, J U, Johnell, O, DeLuca, H F
Format Journal Article
LanguageEnglish
Published United States 01.12.1983
Subjects
Animals
Bone and Bones - drug effects
Bone Resorption - drug effects
Calcitriol - pharmacology
Calcium, Dietary - administration & dosage
Cell Count
Male
Osteoblasts - drug effects
Osteoclasts - drug effects
Phosphorus - administration & dosage
Prednisolone - pharmacology
Rats
Rats, Inbred Strains
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Summary:Adult male rats were treated for six weeks by prednisolone and/or 1,25-(OH)2D3 and given a diet containing either 0.5% calcium or 0.01% Ca and 0.6% phosphorus. Both prednisolone administration and a low-Ca diet were associated with a lower bone mass than that observed in control rats given a 0.5% Ca diet. The percentage of osteoid surface was decreased in rats given prednisolone; these rats also had a lower osteoclast number. The results were consistent with a lower bone turnover during prednisolone treatment. Administration of 1,25-(OH)2D3, resulting in a slightly higher mean level of 1,25-(OH)2D3 in serum, had a positive effect on bone mass, which may be related to increased osteoblastic activity; no increase in the osteoclast number occurred.
ISSN:0009-921X
1528-1132
DOI:10.1097/00003086-198312000-00041