Carbohydrate-containing Triton X-100 analogues for membrane protein solubilization and stabilization

Membrane protein manipulation is a challenging task owing to limited tertiary and quaternary structural stability once the protein has been removed from a lipid bilayer. Such instability can be overcome by embedding membrane proteins in detergent micelles formed from amphiphiles with carefully tuned...

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Published inMolecular bioSystems Vol. 9; no. 4; pp. 626 - 629
Main Authors Chae, Pil Seok, Wander, Marc J, Cho, Kyung Ho, Laible, Philip D, Gellman, Samuel H
Format Journal Article
LanguageEnglish
Published England 05.04.2013
Subjects
Carbohydrates - chemistry
Detergents - chemistry
Membrane Proteins - chemistry
Micelles
Octoxynol - chemistry
Protein Stability
Solubility
Surface-Active Agents - chemistry
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Abstract Membrane protein manipulation is a challenging task owing to limited tertiary and quaternary structural stability once the protein has been removed from a lipid bilayer. Such instability can be overcome by embedding membrane proteins in detergent micelles formed from amphiphiles with carefully tuned properties. This study introduces a class of easy-to-synthesize amphiphiles, which are designated CGT (Chae's Glyco-Triton) detergents. Some of the agents are well suited for membrane protein solubilization and stabilization.
AbstractList Membrane protein manipulation is a challenging task owing to limited tertiary and quaternary structural stability once the protein has been removed from a lipid bilayer. Such instability can be overcome by embedding membrane proteins in detergent micelles formed from amphiphiles with carefully tuned properties. This study introduces a class of easy-to-synthesize amphiphiles, which are designated CGT (Chae's Glyco-Triton) detergents. Some of the agents are well suited for membrane protein solubilization and stabilization.
Membrane protein manipulation is a challenging task owing to limited tertiary and quaternary structural stability once the protein has been removed from a lipid bilayer. Such instability can be overcome by embedding membrane proteins in detergent micelles formed from amphiphiles with carefully tuned properties. This study introduces a class of easy-to-synthesize amphiphiles, which are designated CGT ( C hae’s G lyco- T riton) detergents. Some of the agents are well suited for membrane protein solubilization and stabilization.
Author Laible, Philip D
Gellman, Samuel H
Cho, Kyung Ho
Chae, Pil Seok
Wander, Marc J
AuthorAffiliation b Department of Chemistry, University of Wisconsin-Madison, Madison, WI 53706, USA
c Biosciences Division, Argonne National Laboratory, Argonne, IL 60439, USA
a Department of Bionano Engineering, Hanyang University, Ansan, 426-791, Korea
AuthorAffiliation_xml – name: b Department of Chemistry, University of Wisconsin-Madison, Madison, WI 53706, USA
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  givenname: Pil Seok
  surname: Chae
  fullname: Chae, Pil Seok
  email: pchae@hanyang.ac.kr
  organization: Department of Bionano Engineering, Hanyang University, Ansan, 426-791, Korea. pchae@hanyang.ac.kr
– sequence: 2
  givenname: Marc J
  surname: Wander
  fullname: Wander, Marc J
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Snippet Membrane protein manipulation is a challenging task owing to limited tertiary and quaternary structural stability once the protein has been removed from a...
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StartPage 626
SubjectTerms Carbohydrates - chemistry
Detergents - chemistry
Membrane Proteins - chemistry
Micelles
Octoxynol - chemistry
Protein Stability
Solubility
Surface-Active Agents - chemistry
Title Carbohydrate-containing Triton X-100 analogues for membrane protein solubilization and stabilization
URI https://www.ncbi.nlm.nih.gov/pubmed/23377371
https://pubmed.ncbi.nlm.nih.gov/PMC3593792
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