The Protective Role of Thiourea on Leuciscus cephalus Exposed to Sublethal Doses of Pendigan 330EC (Pendimethalin) Herbicide

• Published in: Bulletin of environmental contamination and toxicology Vol. 97; no. 2; pp. 203 - 210
• Main Authors: Paunescu, Alina, Zgurschi, Gabriela, Soare, Liliana Cristina, Man, George Mihail, Brinzea, Gheorghita, Fierascu, Radu Claudiu, Fierascu, Irina, Ponepal, Maria Cristina
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.08.2016; Springer Nature B.V
• Subjects: Anatomy & physiology; Aniline Compounds - toxicity; Animals; Aquatic Pollution; Biochemistry; Biomarkers - metabolism; Cyprinidae - physiology; Earth and Environmental Science; Ecotoxicology; Environment; Environmental Chemistry; Environmental Health; Fish; Gills - pathology; Hematology; Herbicides; Herbicides - toxicity; Histopathology; Leuciscus cephalus; Liver - chemistry; Oxygen consumption; Pendimethalin; Pollution; Protective Agents - pharmacology; Soil Science & Conservation; Thiourea - pharmacology; Toxicity Tests, Subacute; Waste Water Technology; Water Management; Water Pollutants, Chemical - analysis; Water Pollutants, Chemical - toxicity; Water Pollution Control; Gills histology; Thiourea; Liver histology; Glycaemia; Herbicide
• ISSN: 0007-4861; 1432-0800
• DOI: 10.1007/s00128-016-1834-3

The aim of the study was to investigate the protective role of thiourea on the physiological, hematological, biochemical and histopathological parameters of Leuciscus cephalus exposed to sublethal concentration of Pendigan 330 EC herbicide. The animals were divided in four experimental groups (control, animals subjected to 1 ‰ thiourea, animals subjected to 4 × 10 −4  mL/L herbicide and, respectively, animals subjected to 4 × 10 −4  mL/L herbicide and 1 ‰ thiourea). Exposure of European chub to herbicide administered in water for 2 weeks determined installation of pathological changes in the liver and gills tissues. Also, were observed a decrease in the number of white blood cells and oxygen consumption, breathing frequency, and an increase in the number of red blood cells and glycaemia values. Thiourea counteracts the toxic action, describing itself as normal liver parenchyma and normal gills in animals intoxicated with herbicide, without lesion, and a return to normal values of the studied markers.