High-salt diet accelerates bone loss accompanied by activation of ion channels related to kidney and bone tissue in ovariectomized rats

• Published in: Ecotoxicology and environmental safety Vol. 244; p. 114024
• Main Authors: Cui, Yan, Sun, Kehuan, Xiao, Yawen, Li, Xiaoyun, Mo, Shu, Yuan, Yihan, Wang, Panpan, Yang, Li, Zhang, Ronghua, Zhu, Xiaofeng
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01.10.2022; Elsevier
• Subjects: Bone metabolism; Epithelial sodium channel; High salt diet; Na-Cl cotransporter; Sodium calcium exchanger; Voltage-gated chloride channels; Voltage-gated chloride channels; Na-Cl cotransporter; High salt diet; Epithelial sodium channel; Bone metabolism; Sodium calcium exchanger

Excessive salt intake can induce a variety of diseases, such as hypertension, cardiovascular disease, kidney disease and so on，it is also one of the factors promoting bone resorption. The mechanism of osteoporosis-induced exacerbations of high salt diet is not well-defined. In this study, we used ov...