Improvement in Facial Wrinkles Using Materials Enhancing PPARGC1B Expression Related to Mitochondrial Function

• Published in: Current Issues in Molecular Biology Vol. 46; no. 6; pp. 5037 - 5051
• Main Authors: Lee, Hyejin, Ye, Sanghyun, Kim, Juhyun, Jun, Seung-Hyun, Kang, Nae-Gyu
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 21.05.2024; MDPI
• Subjects: Care and treatment; Collagen; cosmetics; mitochondria function; Scientific equipment and supplies industry; Skin; skin aging; Tranexamic acid; wrinkle improvement; United States; South Korea; Massachusetts; wrinkle improvement; skin aging; mitochondria function; cosmetics
• ISSN: 1467-3045; 1467-3037; 1467-3045
• DOI: 10.3390/cimb46060302

Skin aging is an unavoidable natural phenomenon caused by intrinsic and extrinsic factors. In modern society, the pursuit of a wrinkle-free and aesthetically appealing face has gained considerable prominence. Numerous studies have aimed at mitigating the appearance of facial wrinkles. Antiaging research focused on regulating the function of mitochondria, the main reactive oxygen species-generating organelles, has been extensively conducted. In this study, we investigated the correlation between facial wrinkles and the expression of , considering the association of this gene with mitochondrial function, to identify its potential as a target for exploring antiaging cosmetic materials. We elucidated the role of in the skin and identified five bioactive materials that modulated its expression. The effectiveness of these materials was verified through in vitro experiments on human dermal fibroblasts. We prepared cosmetic formulations incorporating the five materials and confirmed their ability to enhance dermal collagen in three-dimensional skin models and reduce facial wrinkles under the eyes and nasolabial fold areas in human subjects. The study findings have significant implications for developing novel antiaging cosmetic formulations by reinforcing mitochondrial functions.