Magnetic Resonance Imaging for the Detection of High Grade Cancer in the Canary Prostate Active Surveillance Study

• Published in: The Journal of urology Vol. 204; no. 4; pp. 701 - 706
• Main Authors: Liss, Michael A, Newcomb, Lisa F, Zheng, Yingye, Garcia, Michael P, Filson, Christopher P, Boyer, Hilary, Brooks, James D, Carroll, Peter R, Cooperberg, Matthew R, Ellis, William J, Gleave, Martin E, Martin, Frances M, Morgan, Todd, Nelson, Peter S, Wagner, Andrew A, Thompson, Jr, Ian M, Lin, Daniel W
• Format: Journal Article
• Language: English
• Published: United States 01.10.2020
• Subjects: Aged; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neoplasm Grading; Prospective Studies; Prostatic Neoplasms - diagnostic imaging; Prostatic Neoplasms - pathology; Prostatic Neoplasms - therapy; Watchful Waiting; magnetic resonance imaging; prostatic neoplasms
• ISSN: 0022-5347; 1527-3792
• DOI: 10.1097/JU.0000000000001088

We investigated the ability of prostate magnetic resonance imaging to detect Gleason Grade Group 2 or greater cancer in a standardized, multi-institutional active surveillance cohort. We evaluated men enrolled in Canary Prostate Active Surveillance Study with Gleason Grade Group less than 2 and who underwent biopsy within 12 months of multiparametric magnetic resonance imaging. Our primary outcome was biopsy reclassification to Gleason Grade Group 2 or greater. We evaluated the performance of magnetic resonance imaging PI-RADS® score and clinical factors. Multivariable logistic regression models were fit with magnetic resonance imaging and clinical factors and used to perform receiver operating curve analyses. There were 361 participants with 395 prostate magnetic resonance imaging studies with a median followup of 4.1 (IQR 2.0-7.6) years. Overall 108 (27%) biopsies showed reclassification. Defining positive magnetic resonance imaging as PI-RADS 3-5, the negative predictive value and positive predictive value for detecting Gleason Grade Group 2 or greater cancer was 83% (95% CI 76-90) and 31% (95% CI 26-37), respectively. PI-RADS was significantly associated with reclassification (PI-RADS 5 vs 1 and 2 OR 2.71, 95% CI 1.21-6.17, p=0.016) in a multivariable model but did not improve upon a model with only clinical factors (AUC 0.768 vs 0.762). In 194 fusion biopsies higher grade cancer was found in targeted cores in 21 (11%) instances, while 25 (13%) had higher grade cancer in the systematic cores. This study adds the largest cohort data to the body of literature for magnetic resonance imaging in active surveillance, recommending systematic biopsy in patients with negative magnetic resonance imaging and the inclusion of systematic biopsy in patients with positive magnetic resonance imaging.