Bead-Based Cellular Analysis, Sorting and Multiplexing

Functionalized cross‐linked polystyrene microspheres were synthesized, fluorescently labelled and delivered into cells to function as cellular tags and probes (see figure). This allowed the effective delivery of foreign materials into intact mammalian cells, without the need for delicate procedures...

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Bibliographic Details
Published inChembiochem : a European journal of chemical biology Vol. 6; no. 8; pp. 1341 - 1345
Main Authors Sanchez-Martin, Rosario M, Muzerelle, Mathilde, Chitkul, Nutcha, How, Siew Eng, Mittoo, Stifun, Bradley, Mark
Format Journal Article
LanguageEnglish
Published Weinheim Wiley-VCH Verlag 01.08.2005
WILEY-VCH Verlag
WILEY‐VCH Verlag
Subjects
Animals
Biopolymers
Cell Line
Cell Line, Tumor
Cell Separation - methods
drug delivery
Flow Cytometry - methods
Fluorescent Dyes - chemistry
fluorescent probes
Green Fluorescent Proteins - metabolism
Humans
in vitro screening
Microspheres
multifunctionalized microspheres
Particle Size
Polystyrenes - chemistry
Rhodamines - chemistry
Xanthenes - chemistry
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Summary:Functionalized cross‐linked polystyrene microspheres were synthesized, fluorescently labelled and delivered into cells to function as cellular tags and probes (see figure). This allowed the effective delivery of foreign materials into intact mammalian cells, without the need for delicate procedures such as micro‐injection, and did not disrupt cell physiology.
Bibliography:http://dx.doi.org/10.1002/cbic.200500059
istex:C84204A75E138B5C3A68CED194A0C66BEFD086F6
ArticleID:CBIC200500059
ark:/67375/WNG-NLCBQ51P-4
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1439-4227
1439-7633
DOI:10.1002/cbic.200500059