The Effects of Propofol on Local Field Potential Spectra, Action Potential Firing Rate, and Their Temporal Relationship in Humans and Felines

• Published in: Frontiers in human neuroscience Vol. 7; p. 136
• Main Authors: Hanrahan, Sara J., Greger, Bradley, Parker, Rebecca A., Ogura, Takahiro, Obara, Shinju, Egan, Talmage D., House, Paul A.
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Research Foundation 2013; Frontiers Media S.A
• Subjects: Action potential; Anesthesia; Anesthesiology; Consciousness; Electrodes; Electroencephalography; Electrophysiological recording; Firing pattern; Firing rate; Human subjects; Information processing; Intravenous administration; local field potential; microelectrode array; Neocortex; Neuroscience; power spectrum; Propofol; γ-Aminobutyric acid A receptors; United States > US; Japan; power spectrum; local field potential; microelectrode array; consciousness; propofol

Propofol is an intravenous sedative hypnotic, which, acting as a GABAA agonist, results in neocortical inhibition. While propofol has been well studied at the molecular and clinical level, less is known about the effects of propofol at the level of individual neurons and local neocortical networks....