Environmental regulation of virulence factors in Bordetella species

Many bacteria respond in a coordinate manner to environmental changes. External stimuli, sensed by receptors, are transduced to regulatory proteins which participate in well defined pathways of gene expression by varying their structure and mode of action. The network of environmental signal transdu...

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Bibliographic Details
Published inBioEssays Vol. 15; no. 2; p. 99
Main Authors Scarlato, V, Aricó, B, Domenighini, M, Rappuoli, R
Format Journal Article
LanguageEnglish
Published United States 01.02.1993
Subjects
Amino Acid Sequence
Bacterial Proteins - genetics
Bacterial Proteins - metabolism
Bordetella - genetics
Bordetella - pathogenicity
Environment
Gene Expression Regulation, Bacterial
Genes, Bacterial
Models, Biological
Models, Molecular
Molecular Sequence Data
Protein Conformation
Signal Transduction
Transcription Factors - genetics
Transcription Factors - metabolism
Virulence - genetics
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Summary:Many bacteria respond in a coordinate manner to environmental changes. External stimuli, sensed by receptors, are transduced to regulatory proteins which participate in well defined pathways of gene expression by varying their structure and mode of action. The network of environmental signal transduction is responsible for a fine and continuous communication between the host and the pathogenic bacteria. As a result, the gene expression machinery of the pathogen is modified continuously, in order to establish the optimal conditions for bacterial survival and multiplication.
ISSN:0265-9247
DOI:10.1002/bies.950150205