Metabolomics study of different parts of licorice from different geographical origins and their anti‐inflammatory activities

Glycyrrhiza uralensis Fisch., known as licorice, is one of the most famous traditional Chinese medicines. In this study, we perform a metabolome analysis using liquid chromatography–tandem mass spectrometry to assign bioactive components in different parts of licorice from different geographical ori...

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Bibliographic Details
Published inJournal of separation science Vol. 43; no. 8; pp. 1593 - 1602
Main Authors Bai, Haiying, Bao, Fang, Fan, Xiaorui, Han, Shu, Zheng, Wenhui, Sun, Lili, Yan, Na, Du, Hong, Zhao, Haiyu, Yang, Zhigang
Format Journal Article
LanguageEnglish
Published Germany Wiley Subscription Services, Inc 01.04.2020
Subjects
Animals
Anti-Inflammatory Agents - chemistry
Anti-Inflammatory Agents - metabolism
Anti-Inflammatory Agents - pharmacology
anti‐inflammatory activity
Biomarkers
Cell Survival - drug effects
China
Chromatography, Liquid
geographical origin
Glycyrrhiza uralensis - chemistry
Glycyrrhiza uralensis - metabolism
licorice
Lipopolysaccharides - antagonists & inhibitors
Lipopolysaccharides - pharmacology
Liquid chromatography
Macrophages - drug effects
Mass spectrometry
Medicine, Chinese Traditional
Metabolomics
Mice
Nitric Oxide - antagonists & inhibitors
Nitric Oxide - biosynthesis
Origins
RAW 264.7 Cells
Tandem Mass Spectrometry
Traditional Chinese medicine
China
traditional Chinese medicine
licorice
metabolomics
geographical origin
anti-inflammatory activity
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Summary:Glycyrrhiza uralensis Fisch., known as licorice, is one of the most famous traditional Chinese medicines. In this study, we perform a metabolome analysis using liquid chromatography–tandem mass spectrometry to assign bioactive components in different parts of licorice from different geographical origins in Gansu province of China. Sixteen potential biomarkers of taproots from different geographical origins were annotated, such as glycycoumarin, gancaonin Z, licoricone, and dihydroxy kanzonol H mainly exist in the sample of Jiuquan; neoliquiritin, 6′‐acetylliquiritin, licochalcone B, isolicoflavonol, glycyrol, and methylated uralenin mainly exist in Glycyrrhiza uralensis from Lanzhou; gancaonin L, uralenin, and glycybridin I mainly exist in licorice from Wuwei for the first time.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1615-9306
1615-9314
DOI:10.1002/jssc.201901013