Preimplantation diagnosis of the aneuploidies most commonly found in spontaneous abortions and live births: XY, 13, 14, 15, 16, 18, 21, 22

• Published in: Prenatal diagnosis Vol. 18; no. 13; pp. 1459 - 1466
• Main Authors: Munné, Santiago, Magli, Cristina, Bahçe, Muhterem, Fung, Jingly, Legator, Mona, Morrison, Larry, Cohert, Jacques, Gianaroli, Luca
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.12.1998
• Subjects: Abortion, Spontaneous - genetics; Adult; Aneuploidy; Biopsy; Chromosomes, Human, Pair 13; Chromosomes, Human, Pair 14; Chromosomes, Human, Pair 15; Chromosomes, Human, Pair 16; Chromosomes, Human, Pair 18; Chromosomes, Human, Pair 21; Chromosomes, Human, Pair 22; Embryo, Mammalian; Embryonic Development; Female; Humans; In Situ Hybridization, Fluorescence; Pregnancy; Pregnancy Outcome; Prenatal Diagnosis - methods; X Chromosome; Y Chromosome
• ISSN: 0197-3851; 1097-0223
• DOI: 10.1002/(SICI)1097-0223(199812)18:13<1459::AID-PD514>3.0.CO;2-V

The present preimplantation diagnosis test is able to screen for the most common aneuploidies from single blastomeres in about five hours with a 15 per cent misdiagnosis. This means that the risk of spontaneous abortion and trisomic offspring for women of advanced maternal age could be reduced to the same level as younger women for whom prenatal diagnosis is usually not necessary. Better probes and more fluorochromes could improve the success rate of the test. Copyright © 1998 John Wiley & Sons, Ltd.