Propofol and isoflurane induced EEG burst suppression patterns in rabbits

The aim of this study was to compare propofol produced EEG burst suppression with isoflurane produced burst suppression in rabbits and to see whether rabbits can serve as models in studying the effects of different anaesthetics on human EEG. We recorded EEG of eight rabbits anaesthetised with isoflu...

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Bibliographic Details
Published inActa anaesthesiologica Scandinavica Vol. 39; no. 6; p. 814
Main Authors Hartikainen, K, Rorarius, M, Mäkelä, K, Yli-Hankala, A, Jäntti, V
Format Journal Article
LanguageEnglish
Published England 01.08.1995
Subjects
Anesthesia
Anesthetics, Inhalation - pharmacology
Anesthetics, Intravenous - pharmacology
Animals
Electroencephalography - drug effects
Heart Rate - drug effects
Isoflurane - pharmacology
Male
Propofol - pharmacology
Rabbits
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Summary:The aim of this study was to compare propofol produced EEG burst suppression with isoflurane produced burst suppression in rabbits and to see whether rabbits can serve as models in studying the effects of different anaesthetics on human EEG. We recorded EEG of eight rabbits anaesthetised with isoflurane and propofol. The isoflurane bursts had higher amplitude than propofol bursts (P < 0.005). Isoflurane bursts appeared on distinct DC-shifts while propofol bursts were on slow waves. The EEG patterns were, however, different from those seen in humans. Rabbits did not have the rhythms seen in humans. We conclude that rabbits can be used to study the EEG effects of anaesthetics, such as the timing properties and reactivity of burst suppression pattern. However, this model seems less promising in the study of rhythmic activity seen in human EEG during burst suppression.
ISSN:0001-5172
DOI:10.1111/j.1399-6576.1995.tb04176.x