Exchangeable sodium measured serially in DOC-salt, post-DOC-salt, and Goldblatt hypertension in the rat

A method for serial estimation of exchangeable sodium (NaE) levels in rats was developed and validated. The method can detect differences of 0.5 mmol per rat. The NaE level was found to have a constant relationship to the total body sodium content. Changes in the NaE level were found not to be a nec...

Full description

Saved in:
Bibliographic Details
Published inJournal of cardiovascular pharmacology Vol. 6 Suppl 1; p. S126
Main Authors McAreavey, D, Brown, W B, Robertson, J I
Format Journal Article
LanguageEnglish
Published United States 1984
Subjects
Animals
Blood Pressure
Body Weight
Desoxycorticosterone
Drinking
Hypertension - chemically induced
Hypertension - metabolism
Hypertension - physiopathology
Kidney - physiology
Male
Nephrectomy
Rats
Rats, Inbred Strains
Renin - blood
Sodium - metabolism
Online AccessGet more information

Cover

More Information
Summary:A method for serial estimation of exchangeable sodium (NaE) levels in rats was developed and validated. The method can detect differences of 0.5 mmol per rat. The NaE level was found to have a constant relationship to the total body sodium content. Changes in the NaE level were found not to be a necessary accompaniment of two-kidney, one-clip hypertension. The NaE level was increased throughout 6 weeks of one-kidney, one-clip hypertension and reverted to control values with relief of hypertension after unclipping. The NaE level increased during the development of deoxycorticosterone (DOC)-salt hypertension but subsequently decreased during post-DOC-salt hypertension, although blood pressure remained elevated. Thus an increased NaE level was not necessary for the persistence of post-DOC hypertension.
ISSN:0160-2446
DOI:10.1097/00005344-198400061-00022