Lanthanide‐doped rare earth nanoparticles for near‐infrared‐II imaging and cancer therapy

The optical nanoprobes with emissions in the second near‐infrared window (NIR‐II, 1000–1700 nm) show low tissue autofluorescence and photon scattering; therefore, they provide high spatial resolution and acceptable tissue penetration depth. These advantages make them appropriate for in vivo applicat...

Full description

Saved in:
Bibliographic Details
Published inBMEmat (Print) Vol. 1; no. 3
Main Authors Zhao, Hongxia, Xiao, He, Liu, Ying, Ju, Huangxian
Format Journal Article
LanguageEnglish
Published Jinan John Wiley & Sons, Inc 01.09.2023
Wiley
Subjects
Aqueous solutions
bioimaging
cancer theranostics
Cancer therapies
Energy
Information storage
lanthanide‐doped nanoparticles
Light
Medical diagnosis
Nanoparticles
NIR‐II fluorescence
Polyethylene glycol
Radiation
second near‐infrared window
Tomography
Online AccessGet full text

Cover

More Information
Summary:The optical nanoprobes with emissions in the second near‐infrared window (NIR‐II, 1000–1700 nm) show low tissue autofluorescence and photon scattering; therefore, they provide high spatial resolution and acceptable tissue penetration depth. These advantages make them appropriate for in vivo applications, including bioimaging, NIR‐II triggered disease therapy, and even on‐site efficacy monitoring. Among the various developed NIR‐II fluorescence probes, lanthanide‐doped nanoparticles (LDNPs) exhibit high photo stability and narrow emission bandwidths with long photoluminescence lifetimes and low cytotoxicity; therefore, they have been widely studied in the biomedical field. This review summarizes the typical compositions and optical properties of recently developed NIR‐II emitting LDNPs. Their applications in in vivo NIR‐II bioimaging and cancer therapy are reviewed. The perspectives and challenges of NIR‐II LDNPs are also discussed. Lanthanide‐doped nanoparticles (LDNPs) offer various emissions in the NIR‐II region by co‐doping different rare earth metal ions. This review summarizes different sensitizer ions for LDNPs with NIR‐II emissions, and their applications in “always on” in vivo imaging, activatable in vivo imaging, and NIR‐II imaging‐guided therapy. NIR‐II imaging guided theranostics provides controllable responsiveness, high resolution, improved penetration depth and low background interference.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ISSN:2751-7438
2751-7446
DOI:10.1002/bmm2.12032